TOP 10 Weekend getaways in St. Louis, Missouri

Located in the heart of downtown St. Louis, the 21c Museum Hotel St. Louis is a unique lodging experience that combines a boutique hotel with a contemporary art museum. Housed in a historic YMCA building, the hotel features 173 rooms, a restaurant, cafe, and a full-service wellness center. With over 14,000 square feet of exhibition and event space, guests can immerse themselves in contemporary art around every corner. The hotel offers a variety of room options, from twin beds to spacious suites, each with modern amenities and unique historic features. Guests can also enjoy dining credits, free parking, and special packages during their stay. The hotel is committed to fostering innovation and community engagement through its programming and events, making it a vibrant cultural hub in the city. Whether you're visiting for a weekend getaway or a special event, the 21c Museum Hotel St. Louis offers a truly one-of-a-kind experience.

Explore St. Louis is a vibrant institution located at 701 Convention Plaza in St. Louis, Missouri, United States. This institution offers a wide range of activities and attractions for visitors of all ages, from iconic landmarks to hidden gems and natural landscapes. Visitors can immerse themselves in architectural wonders, paddle down the Mighty Mississippi, and admire world-class art in free museums. The institution also hosts a variety of events such as art exhibitions, live music performances, food festivals, and sports games. With guides to help plan personalized itineraries, visitors can explore the city's historic sites, restaurants, breweries, and more. Whether you're seeking outdoor adventures, cultural experiences, or culinary delights, Explore St. Louis has something for everyone. Come and discover the best that St. Louis has to offer!

Hyatt Regency St. Louis At The Arch is a luxurious lodging institution located at 315 Chestnut Street in the heart of St. Louis, Missouri, United States. Situated just steps away from the iconic Gateway Arch, this hotel offers stunning views of the city skyline and easy access to top attractions. With spacious and elegantly appointed rooms, top-notch amenities, and exceptional service, Hyatt Regency St. Louis At The Arch provides a truly unforgettable stay for both leisure and business travelers. Whether you're visiting for a weekend getaway or a corporate event, this hotel is the perfect choice for a memorable experience in St. Louis.

Wingate by Wyndham St. Louis Airport is a comfortable and convenient lodging option located at 10820 Pear Tree Drive in Saint Ann, Missouri, United States. This hotel offers spacious and modern rooms, complimentary breakfast, free airport shuttle service, fitness center, and indoor pool. Whether you are in town for business or leisure, Wingate by Wyndham St. Louis Airport provides a welcoming and relaxing atmosphere for all guests.

Fairfield Inn & Suites by Marriott St. Louis St. Charles is a comfortable and convenient lodging option located at 801 Veterans Memorial Parkway in Saint Charles, Missouri, United States. This hotel offers spacious and modern rooms, a complimentary breakfast buffet, a fitness center, an indoor pool, and free high-speed Wi-Fi. Guests can enjoy easy access to nearby attractions such as the historic Main Street district, Ameristar Casino, and the St. Charles Convention Center. Whether traveling for business or leisure, Fairfield Inn & Suites provides a welcoming and relaxing stay for all guests.

Hollywood Casino & Hotel St. Louis is a premier entertainment destination located at 777 Casino Center Drive in Maryland Heights, Missouri. As a casino institution, it offers a wide range of exciting gaming options, including slots, table games, and poker. In addition to the thrilling casino experience, guests can enjoy luxurious accommodations at the hotel, as well as delicious dining options, live entertainment, and a vibrant nightlife scene. Whether you're looking for a fun night out with friends or a relaxing weekend getaway, Hollywood Casino & Hotel St. Louis has something for everyone. Come and experience the excitement and glamour of Hollywood right in the heart of Missouri.

The Best Western St. Louis Inn is a comfortable and convenient lodging option located at 6224 Heimos Industrial Park Drive in St. Louis, Missouri. This charming hotel offers a range of amenities including spacious rooms, free breakfast, a fitness center, and a seasonal outdoor pool. Whether you are visiting for business or leisure, the Best Western St. Louis Inn is the perfect place to relax and unwind during your stay in the vibrant city of St. Louis.

The Residence Inn by Marriott St. Louis Clayton is a comfortable and convenient lodging option located at 8125 Forsyth Boulevard in the charming city of Clayton, Missouri. This hotel offers spacious suites with fully equipped kitchens, complimentary breakfast, and free Wi-Fi. Guests can enjoy amenities such as a fitness center, outdoor pool, and on-site dining options. The hotel's central location allows easy access to local attractions, dining, and shopping in the St. Louis area. Experience a relaxing and enjoyable stay at Residence Inn by Marriott St. Louis Clayton.

Drury Inn & Suites St. Louis Brentwood is a charming lodging establishment located at 8700 Eager Road in Brentwood, Missouri, United States. This cozy hotel offers comfortable rooms and suites, perfect for both leisure and business travelers. Guests can enjoy amenities such as free breakfast, Wi-Fi, and parking, as well as access to a fitness center and indoor pool. The hotel's convenient location provides easy access to nearby attractions, restaurants, and shopping options. Whether you're visiting for a weekend getaway or a work trip, Drury Inn & Suites St. Louis Brentwood is the perfect home away from home.

Aloft St. Louis Cortex is a modern and stylish lodging institution located at 4245 Duncan Avenue in the heart of St. Louis, Missouri. This trendy hotel offers comfortable and contemporary accommodations for guests visiting the vibrant Cortex Innovation Community. With its convenient location, guests can easily access nearby attractions, restaurants, and businesses. The hotel features sleek and spacious rooms, a fitness center, a vibrant bar, and a relaxing outdoor patio. Whether traveling for business or leisure, Aloft St. Louis Cortex provides a unique and welcoming experience for all guests.

Comfort Suites St. Louis - Sunset Hills is a cozy and welcoming lodging institution located at 3654 South Lindbergh Boulevard in St. Louis, Missouri, United States. This hotel offers spacious and comfortable suites, perfect for both leisure and business travelers. Guests can enjoy amenities such as complimentary breakfast, free WiFi, a fitness center, and an indoor pool. The convenient location allows easy access to popular attractions in St. Louis, making it an ideal choice for those looking for a relaxing and enjoyable stay.

The Greater St Charles Convention and Visitors Bureau is a travel agency located at 230 South Main Street in Saint Charles, Missouri, United States. Experience over 250 years of Saint Charles history in just one hour with our guided tours offered on most Fridays, Saturdays, and Sundays. Just a short drive from St. Louis, Saint Charles offers a unique historical perspective, beautiful sites, friendly people, and a relaxed pace. Founded as Les Petites Cotes by French Canadian fur trader Louis Blanchette, Saint Charles has grown into a thriving riverfront trading center. The Builders St. Charles Home Show, held annually in April at the St. Charles Convention Center, offers free admission and parking. Enjoy free concert band music and big band jazz with a vocalist. Visit St. Charles Flea, a high-end flea market in Old St. Charles. Explore fresh produce and crafts from local vendors while enjoying live music.

Extended Stay America - St. Louis - Westport - Central is a comfortable and convenient lodging option located at 12161 Lackland Road in St. Louis, Missouri. This institution offers spacious rooms equipped with full kitchens, making it ideal for guests looking for a longer stay. The central location in the Westport area provides easy access to nearby attractions, restaurants, and shopping centers. Guests can enjoy amenities such as free WiFi, on-site laundry facilities, and a complimentary grab-and-go breakfast. Whether traveling for business or leisure, Extended Stay America - St. Louis - Westport - Central provides a home away from home experience for all guests.

Shelley House is a historic institution located at 4600 Labadie Avenue in St. Louis, Missouri. This beautiful house is a symbol of elegance and sophistication, offering a unique blend of history and modern amenities. Visitors can explore the stunning architecture and charming surroundings, while also learning about the rich history of the house and its significance in the community. Whether you are looking to host a special event, attend a cultural program, or simply enjoy a peaceful retreat, Shelley House is the perfect destination for those seeking a truly memorable experience.

Historic Hill is a charming area within the Saint Louis Zoo, located at 1 Government Drive in St. Louis, Missouri. It offers a nostalgic journey through time, with attractions dating back to the 1904 World’s Fair and the 1920s Spanish architectural style. Visitors can explore a variety of exhibits, including the Bird House, Primate House, and Herpetarium, each with its own unique ambiance. One of the highlights of Historic Hill is the colorful bird exhibit, where visitors can observe resident birds in a lush and scenic environment. Inside the Mediterranean-style building, guests can explore four different climates housing reptiles and amphibians from around the world.

Your Friend’s Apartment is a trendy boutique located on Cherokee Street in St. Louis, Missouri. This unique store offers a curated selection of clothing, furniture, home goods, and shoes, making it the perfect one-stop shop for all your fashion and home decor needs. With a cozy and inviting atmosphere, Your Friend’s Apartment feels like shopping at a stylish friend’s house. Whether you’re looking for a new outfit, a statement piece of furniture, or the perfect pair of shoes, you’re sure to find something special at this eclectic store. Visit Your Friend’s Apartment at 2617 Cherokee Street and discover a shopping experience unlike any other.

1 Nite Stand is a lively bar located at 2800 Ohio Avenue in St. Louis, Missouri. Known for its vibrant atmosphere, delicious drinks, and friendly staff, this institution is the perfect spot for a fun night out with friends. Whether you're looking to dance the night away or just relax with a cocktail, 1 Nite Stand has something for everyone. So come on down and experience a night to remember at 1 Nite Stand!

SKECHERS Factory Outlet at 18521 Outlet Boulevard in Chesterfield, Missouri, offers a wide selection of footwear for every occasion. From casual shoes for men and women to sturdy and stylish kids' shoes, as well as athletic sneakers for weekend adventures, SKECHERS has something for the whole family. Enroll in store for exclusive offers and use our Shoe Finder to discover the perfect pair. Don't miss out on our recurring automated promotional and personalized marketing text messages to stay up to date with the latest deals. Visit our St. Louis Premium Outlet location in Chesterfield today!

Washington Avenue Bistro is a charming restaurant located at 827 Washington Avenue in the heart of St. Louis, Missouri. This cozy bistro offers a warm and inviting atmosphere, perfect for a casual lunch or a romantic dinner. The menu features a variety of delicious dishes, including classic American fare and international cuisine. Guests can enjoy a selection of handcrafted cocktails, fine wines, and local beers to complement their meal. With its friendly staff and top-notch service, Washington Avenue Bistro is a must-visit dining destination in St. Louis.

Lakeside Inn is a charming lodging establishment located at 10600 Veterans Memorial Parkway in Lake Saint Louis, Missouri, United States. Situated right by the tranquil waters of a picturesque lake, Lakeside Inn offers guests a peaceful retreat away from the hustle and bustle of everyday life. The inn features comfortable rooms with scenic views, a cozy lobby area with a fireplace, and a welcoming staff dedicated to ensuring a pleasant stay for all visitors. Whether you are visiting for a relaxing weekend getaway or a business trip, Lakeside Inn provides a serene and inviting atmosphere for guests to enjoy.

The Lodge Hotel and Banquets, located at 3551 Pennridge Drive in Bridgeton, Missouri, offers a serene and sophisticated experience for guests. Embrace tranquility and refined style in our stylish haven. Enjoy luxury accommodations with amenities such as a heated indoor pool, hot tub, and 43” flat screen TVs in every room. Conveniently located near Interstate 270 and Interstate 70, the hotel is just a short drive from St. Louis Lambert International Airport. Explore nearby attractions such as the Gateway Arch, Busch Stadium, and various casinos. Whether you're looking for a weekend getaway or an extended stay, The Lodge Hotel is the perfect choice for comfort and convenience. Book your room now and experience the ultimate in relaxation and elegance.

CozySuites Central West End is a charming lodging facility located at 4215 Lindell Boulevard in the vibrant city of St. Louis, Missouri. Situated in the heart of the Central West End neighborhood, this institution offers comfortable and stylish accommodations for travelers looking to explore all that the city has to offer. With its convenient location, guests can easily access nearby attractions, restaurants, and shops. The cozy atmosphere and friendly staff make CozySuites Central West End the perfect choice for a relaxing stay in St. Louis.

Springdale Motel is a cozy and comfortable lodging option located at 4121 Springdale Avenue in the vibrant city of St. Louis, Missouri. Situated in a convenient location, guests can easily access popular attractions, restaurants, and shopping destinations. The motel offers clean and spacious rooms equipped with modern amenities to ensure a relaxing stay for all guests. Whether visiting for business or leisure, Springdale Motel provides a welcoming atmosphere and friendly service to make your stay in St. Louis truly memorable.

Wayside Motel is a cozy and convenient lodging option located at 7800 Watson Road in St. Louis, Missouri. Offering comfortable rooms and friendly service, this motel is the perfect choice for travelers looking for a budget-friendly stay in the heart of the city. With easy access to nearby attractions and amenities, Wayside Motel provides a relaxing and enjoyable experience for guests visiting St. Louis. Whether you're in town for business or leisure, you'll find everything you need for a pleasant stay at Wayside Motel.

Budget Inn is a cozy lodging establishment located at 3607 Hamilton Avenue in St. Louis, Missouri. Offering affordable rates and comfortable accommodations, Budget Inn is the perfect choice for budget-conscious travelers looking for a convenient place to stay. The inn provides clean and spacious rooms, friendly staff, and easy access to nearby attractions and amenities. Whether you are visiting St. Louis for business or pleasure, Budget Inn is a great option for your stay.

The MANCAVE is a unique lodging experience located at 916 Olive Street in the heart of St. Louis, Missouri. This one-of-a-kind institution offers a haven for those seeking a retreat from the everyday hustle and bustle. With its masculine and stylish decor, The MANCAVE provides a comfortable and inviting atmosphere for guests to relax and unwind. Whether you're in town for business or pleasure, The MANCAVE is the perfect place to call home during your stay in St. Louis.

Ivy Motel is a charming lodging establishment located at 10143 Old Olive Street Road in St. Louis, Missouri. This cozy motel offers comfortable and affordable accommodations for travelers looking for a convenient place to stay. The rooms at Ivy Motel are well-appointed and feature modern amenities to ensure a pleasant stay for guests. Whether you are visiting St. Louis for business or pleasure, Ivy Motel is the perfect choice for your accommodation needs. Experience warm hospitality and excellent service at Ivy Motel during your stay in the United States.

La Maison is a charming institution located at 3530 Utah Street in St. Louis, Missouri, United States. This cozy establishment offers a variety of services and activities for its patrons to enjoy. From delicious cuisine to relaxing spa treatments, La Maison is the perfect place to unwind and indulge in luxury. Whether you are looking for a romantic getaway or a weekend retreat, La Maison has something for everyone. Come visit us and experience the beauty and tranquility of this hidden gem in the heart of St. Louis.

La Herradura De Baule is a cozy bar located at 9361 Natural Bridge Road in St. Louis, Missouri. This institution offers a warm and inviting atmosphere where patrons can relax and enjoy a wide selection of drinks and cocktails. With friendly staff and a welcoming environment, La Herradura De Baule is the perfect spot to unwind after a long day or catch up with friends over a few drinks. Whether you're looking for a casual night out or a lively gathering, this bar has something for everyone. Come visit La Herradura De Baule and experience the charm of this local establishment.

Raise The Bar Travel Group is a premier institution located in St. Peters, Missouri, United States. Specializing in health, real estate agency, and travel agency services, RTB Travel Group offers all-inclusive vacations to destinations such as the Caribbean, as well as destination weddings from Saint Louis. With over 25 years of combined travel experience, the team at Raise The Bar Travel Group is dedicated to providing you with the best travel experience possible. Whether you're looking for a weekend getaway or a year-long cruise, our experienced agents are here to assist you. We specialize in destination weddings, cruises, adults-only and family vacations, guided and independent tours, and group travel.