The 30 Best Main street dining in Tupelo, Mississippi

Lost Pizza Co. Tupelo West Main is a funky and fresh pizza joint located at 3418 West Main Street in Tupelo, Mississippi. Born in the Mississippi Delta, this restaurant serves up delicious pizzas made with fresh ingredients. Founded by roommates Brooks Roberts & Preston Lott, Lost Pizza Co. offers a fun and laid-back atmosphere where friends can enjoy cold beers and the best pizzas they've ever tasted. Order online or download the mobile app to satisfy your pizza cravings with just a tap. Stay updated with the latest news and enjoy the made-from-scratch Ranch dressing available for purchase. Join us for great opportunities in a booming family business and don't miss out on special events like the Live with the Red Wolves Basketball Radio Show. Lost Pizza Co. was recently featured in PMQ Pizza Magazine and VIE Magazine. Come get lost with Lost Pizza Co. and find a slice near you!

Vanelli's Bistro is a charming restaurant located at 206 West Main Street in Tupelo, Mississippi. Known for its cozy atmosphere and delicious cuisine, this bistro offers a diverse menu featuring a variety of dishes to suit every palate. From savory appetizers to delectable entrees and decadent desserts, Vanelli's Bistro is the perfect spot for a casual meal or special occasion. Whether you're looking for a quick bite to eat or a leisurely dining experience, this establishment is sure to satisfy your cravings. Come and experience the culinary delights of Vanelli's Bistro today!

Cafe 212 is a charming restaurant located at 212 West Main Street in Tupelo, Mississippi. Known for its cozy atmosphere and delicious food, Cafe 212 offers a diverse menu featuring a variety of dishes to satisfy any craving. Whether you're in the mood for a hearty sandwich, a fresh salad, or a decadent dessert, Cafe 212 has something for everyone. Stop by for a casual lunch with friends or a romantic dinner for two. With its convenient location and welcoming staff, Cafe 212 is the perfect spot to enjoy a tasty meal in Tupelo.

Located at 2465 West Main Street in Tupelo, Mississippi, McDonald's is a popular cafe, food, restaurant, and store offering a range of menu items to satisfy your cravings. Our Terms and Conditions have recently changed, so please take a moment to review them before ordering. You can now conveniently order and pay for your food through the Mobile Order & Pay app on iOS or Android and pick it up at the store. If you prefer delivery, McDelivery is available on various apps like DoorDash, Uber Eats, Grubhub, or Postmates, with Uber Eats also available through the McDonald's app. Menu items may vary by location, so make sure to check the app for availability. You can also register your payment cards in the app for easy payment options. Our top priority is the health and safety of our employees and customers, and we have implemented various safety measures to ensure a safe dining experience. Visit us today to enjoy your favorite McDonald's meals at an affordable price!

Park Heights Restaurant is a premier dining destination in Tupelo, Mississippi, offering Creative Southern and American Cuisine. Located in the Fairpark District at 335 East Main Street, this restaurant is known for its modern American menu featuring dishes like grilled oysters, she crab soup, foie gras, butter poached Alaskan halibut, lobster pot pie, and prime cuts of beef. The ambiance in the main dining room is sophisticated yet relaxed, with reclaimed hardwood floors and retro lighting creating a welcoming atmosphere. The service at Park Heights is professional and gracious, and the extensive wine list is sure to please even the most discerning palate. For a unique dining experience, guests can enjoy the rooftop or patio seating with stunning views of downtown Tupelo. Visit Park Heights Restaurant for a memorable culinary experience that is truly one of the best in town.

Nautical Whimsey Italian is a charming bar and restaurant located at 210 West Main Street in Tupelo, Mississippi. Step inside and be transported to a cozy Italian seaside retreat, complete with nautical decor and whimsical touches. Indulge in delicious Italian cuisine, from classic pasta dishes to fresh seafood specialties, all expertly prepared by our talented chefs. Sip on handcrafted cocktails or choose from our extensive wine list as you unwind and enjoy the laid-back atmosphere. Whether you're looking for a romantic dinner for two or a fun night out with friends, Nautical Whimsey Italian is the perfect spot for a memorable dining experience.

Fairpark Grill is a cozy and inviting bar and restaurant located at 343 East Main Street in Tupelo, Mississippi. Known for its delicious food and friendly atmosphere, Fairpark Grill is a popular spot for locals and visitors alike. Whether you're looking for a hearty meal, a refreshing drink, or just a place to unwind with friends, Fairpark Grill has something for everyone. Come in and experience the warm hospitality and mouthwatering dishes that make Fairpark Grill a must-visit destination in Tupelo.

New China Chinese Restaurant is located at 2218 West Main Street in Tupelo, Mississippi. Our restaurant offers authentic and delicious Chinese cuisine that is sure to satisfy your cravings. Whether you choose to dine-in or take-out, our convenient location and affordable prices make us a popular choice in the Tupelo community. Known for our wide variety of flavors and high-quality ingredients, you can expect a top-notch dining experience at New China. Our friendly atmosphere and excellent service will make you feel right at home. Come visit us today and taste the difference at New China Chinese Restaurant.

Hardee's is a popular fast food restaurant located at 477 East Main Street in Tupelo, Mississippi. Known for their delicious burgers, chicken sandwiches, and breakfast items, Hardee's offers a wide variety of tasty options for customers to enjoy. With a convenient location and friendly staff, Hardee's is a great place to grab a quick and satisfying meal in the heart of Tupelo. Whether you're looking for a hearty breakfast to start your day or a satisfying lunch or dinner, Hardee's has something for everyone. Visit us today and see why Hardee's is a favorite dining destination in Tupelo!

Jack's is a popular food institution located at 2609 West Main Street in Tupelo, Mississippi, United States. Known for its delicious Southern hospitality, Jack's offers a variety of mouthwatering dishes that are sure to satisfy your cravings. With the Jack's app on iOS or Android, you can easily order your favorite meals and earn points for future purchases. Don't miss out on the new French Toast Sticks or the Boneless Wings Big Box, perfect for feeding the family or enjoying on your own. With locations in Alabama, Tennessee, Georgia, and Mississippi, Jack's is truly All About the South. Download the Jack's app today to start saving with exclusive offers and rewards with every order. And if you're looking for a job you love, Jack's is the place to be where you can have a say in your hours, make a difference in your community, and learn to make a true Southern biscuit. Visit Jack's today and experience the best of Southern cuisine!