Top 30 Best American cuisine in Clarksdale, Mississippi

Delta Bohemian Tours offers immersive and authentic experiences in the heart of the Mississippi Delta. Located in Clarksdale, Mississippi, this institution provides guided tours that showcase the rich history, culture, and music of the region.

Pete's Grill is a popular bar and restaurant located at 550 Sunflower Avenue in Clarksdale, Mississippi. Known for its delicious food and laid-back atmosphere, Pete's Grill is a favorite spot for locals and visitors alike.

Kenoy's is a beloved food institution located at 4125 Friars Point Road in Clarksdale, Mississippi. Known for its delicious and authentic Southern cuisine, this restaurant offers a variety of dishes that are sure to satisfy any craving.

Owens Burger Shack is a popular food destination located at 601 Doctor Martin Luther King Jr. Boulevard in Clarksdale, Mississippi. This cozy restaurant offers a variety of delicious burgers, fries, and shakes in a casual and welcoming atmosphere.

Welcome to Our Grandma's House of Pancakes, a cozy and charming restaurant located at 115 3rd Street in Clarksdale, Mississippi.

Hicks Tamales & BBQ Shop is a beloved institution located at 305 South State Street in Clarksdale, Mississippi. This unique establishment offers a delicious combination of traditional tamales and mouthwatering BBQ dishes.

Tiger 1 Mart is a popular food establishment located at 529 North State Street in Clarksdale, Mississippi. This cozy restaurant offers a diverse menu featuring delicious dishes from various cuisines.

Ground Zero Blues Club is a legendary night club located in the heart of Clarksdale, Mississippi. Situated at 387 Delta Avenue, this iconic institution is a mecca for blues music enthusiasts from around the world.

Rest Haven is a cozy and welcoming restaurant located at 419 South State Street in Clarksdale, Mississippi. Known for its delicious comfort food and friendly atmosphere, this institution is a popular choice for locals and visitors alike.

Pearl 88 is a charming restaurant located at 1410 North State Street in Clarksdale, Mississippi. Known for its delicious and authentic cuisine, Pearl 88 offers a diverse menu of food options that are sure to satisfy any craving.

Crossroad’s Catfish is a renowned restaurant located at 906 North State Street in Clarksdale, Mississippi. Specializing in serving delicious catfish dishes, this institution offers a cozy and inviting atmosphere for guests to enjoy a satisfying meal.

Yazoo Pass is a charming cafe and restaurant located at 207 Yazoo Avenue in the heart of Clarksdale, Mississippi. This popular spot offers a delicious menu of Southern comfort food, specialty coffee drinks, and sweet treats.

Bluesberry Cafe is a cozy and inviting eatery located at 235 Yazoo Avenue in Clarksdale, Mississippi. Known for its laid-back atmosphere and delicious Southern cuisine, this cafe is a favorite spot for locals and visitors alike.

Stone Pony Pizza is a cozy and inviting bar and restaurant located at 226 Delta Avenue in Clarksdale, Mississippi. Known for its delicious and mouth-watering pizzas, Stone Pony Pizza offers a wide variety of toppings and crusts to satisfy every craving.

Ramon's is a charming restaurant located at 535 Oakhurst Avenue in Clarksdale, Mississippi. Known for its delicious food and welcoming atmosphere, Ramon's offers a diverse menu of mouthwatering dishes served in a cozy setting.

Abe's Bar-B-Q is a beloved institution located at 616 North State Street in Clarksdale, Mississippi.

Bobbie's Diner is a charming restaurant located at 1208 North State Street in Clarksdale, Mississippi. This beloved diner is a local favorite, known for its delicious comfort food and friendly atmosphere.

Wendy's is a popular fast food restaurant located at 623 South State Street in Clarksdale, Mississippi. Known for their delicious burgers, fries, and frosty treats, Wendy's offers a wide variety of menu options to satisfy any craving.

Lil Sistas is a cozy and welcoming restaurant located at 282 Sunflower Avenue in Clarksdale, Mississippi. Specializing in delicious comfort food and southern cuisine, Lil Sistas offers a variety of mouthwatering dishes that will leave you wanting more.

Snack Shack is a cozy and inviting restaurant located on Evelyn Avenue in Clarksdale, Mississippi. Known for its delicious and affordable snacks, this eatery is a popular choice for locals and visitors alike.

The Little Red Shed is a charming restaurant located at 220 Yazoo Avenue in Clarksdale, Mississippi. This cozy eatery offers a unique dining experience with a menu featuring delicious comfort food and Southern classics.

Sweet Tooth Teddy, LLC is a delightful bakery and food store located at 282 Sunflower Avenue in Clarksdale, Mississippi.

Domino's Pizza at 640 Desoto Avenue in Clarksdale, Mississippi, is a popular restaurant specializing in delicious pizza and other Italian-American cuisine.

Hong Kong Market is a bustling grocery store located at 1120 Doctor Martin Luther King Jr. Boulevard in Clarksdale, Mississippi. This Asian-inspired market offers a wide variety of fresh produce, pantry staples, and specialty items.

Delta Blues Alley Cafe is a historic bar located at 352 Delta Avenue in Clarksdale, Mississippi. It is known as the Birthplace of American Music Festival, a celebration of the Blues and its influence on various music genres.

Messengers Pool Hall and Cafe is a vibrant and lively establishment located in the heart of Clarksdale, Mississippi. Situated on Doctor Martin Luther King Jr.

Ramon's Restaurant is a cozy and welcoming dining establishment located in Clarksdale, Mississippi. Situated at 300 North Edwards Avenue, this popular restaurant offers a diverse menu of delicious dishes that are sure to satisfy any craving.

Grillers Heaven is a popular restaurant located at 510 North State Street in Clarksdale, Mississippi. Known for its delicious grilled dishes and heavenly flavors, this institution is a must-visit for food lovers in the area.

Delta Blues Alley Cafe is located at 352 Delta Avenue in Clarksdale, Mississippi, United States. It is the Birthplace of American Music Festival, a musical event that pays homage to the roots of American music - the Blues.

The Compound at the Crossroads is a charming restaurant located at 1108 Desoto Avenue in Clarksdale, Mississippi.