The 30 Best Main street restaurants in Buffalo, Missouri

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Buffalo Wild Wings is a popular restaurant located at 231 North Main Street in Sikeston, Missouri. Known for their delicious wings and wide variety of sauces, this establishment is a favorite spot for sports fans and food enthusiasts alike. With a casual and lively atmosphere, Buffalo Wild Wings is the perfect place to enjoy a meal with friends and family while catching the latest game on one of their many big screen TVs. Whether you're craving traditional bone-in wings or boneless options, this restaurant has something for everyone. Come visit Buffalo Wild Wings for a fun and flavorful dining experience in Sikeston.

Zaxby's Chicken Fingers & Buffalo Wings is a popular restaurant located at 1057 South Main Street in Sikeston, Missouri. Known for their delicious chicken fingers and buffalo wings, Zaxby's offers a variety of mouth-watering menu options for both dine-in and takeout. Whether you're looking for a quick meal on the go or a casual dining experience, Zaxby's is the perfect choice for indulging in flavorful and satisfying dishes. Experience the perfect blend of savory flavors and quality ingredients at Zaxby's Chicken Fingers & Buffalo Wings.

Fat Boy's Saloon & Grill is the ultimate destination for relaxation and good times in De Soto, Missouri. Located at 301 East Main Street, our bar and restaurant offers a laid-back atmosphere where you can unwind with a drink in hand while watching TV. Our establishment wouldn't be complete without a variety of games to enjoy, including pool and air hockey. And when it comes to food, we have a delicious menu featuring items like lightly breaded green beans, stuffed mushrooms, buffalo chicken bites, and more. Our signature dishes include loaded pulled pork chips, crispy potato fries, and cheesy pepperoni bites.

Subway is a popular fast food restaurant located at 1112 Main Street in Buffalo, Missouri. Known for their delicious and customizable sandwiches, salads, and wraps, Subway offers a wide variety of fresh and healthy options for customers to choose from. Whether you're looking for a quick lunch on the go or a satisfying meal with friends and family, Subway has something for everyone. With friendly service and affordable prices, Subway is a go-to destination for those craving a tasty and convenient dining experience.