The Best Historical lodging options in Yazoo City, Mississippi

The Main Street Hotel is a charming lodging option located on historic Main Street in Yazoo City, Mississippi. Each hotel suite offers a unique ambiance with balcony access and street views. The rooms are elegantly decorated with fine linens, antique furniture, and bathrooms featuring claw-foot tubs and showers. The hotel does not allow pets and is a non-smoking property. The reception hall, "The No Smoking Smoke House," is available for events such as wedding receptions, reunions, business meetings, and parties. Book your stay at The Main Street Hotel for a fun and unique experience in Yazoo City. Contact us at (662) 751-8886 or mainsthotel@yahoo.com.