Immunotherapy in Natick, Massachusetts

The BioInnovations Institute - CyTOF Mass Cytometry Core, located at 17 Erie Drive in Natick, Massachusetts, is a federally-funded research facility dedicated to advancing basic, applied, and clinical research in collaboration with academic, biotech, and pharmaceutical industries. The core facility houses a CyTOF mass cytometer, allowing researchers to analyze biomarkers at the single cell level and gain system-level comprehension with single-cell resolution. With over 400 metal-conjugated antibodies available for human and mouse targets, researchers can design high-dimensional proteomic panels using an interactive, web-based application. The facility also offers Maxpar™ Sample Prep Buffers and Fluidigm-validated protocols for optimal mass cytometry staining performance. The Helios system, equipped with barcoding technology, increases throughput and data quality, enabling researchers to analyze more experimental variables simultaneously. Mass cytometry employs heavy metal isotope tags for simultaneous measurement of multiple cellular targets, with high-purity metallic isotopes ensuring minimal background interference. With a range of 135 channels, the Helios system allows for comprehensive studies and scalability for future developments in metal tagging technology. Fluidigm offers individual metal-tagged antibodies and preassembled kits for specific applications, providing researchers with over 50 unique tags for use in mass cytometry experiments. With a modern, intuitive user interface and analysis tools such as dot plots and clustering algorithms, the CyTOF Mass Cytometry Core at BioInnovations Institute is at the forefront of cutting-edge research in cellular analysis and biomarker discovery.