The 30 Best American small business in Murphysboro, Illinois

St. Nicholas Brewing Co. MDH is a cozy and inviting restaurant located at 665 North Airport Road in Murphysboro, Illinois. Known for its delicious food and craft beers, this institution offers a unique dining experience for locals and visitors alike. The menu features a variety of dishes made with fresh, locally sourced ingredients, as well as a rotating selection of handcrafted beers brewed on site. Whether you're looking for a casual meal with friends or a special night out, St. Nicholas Brewing Co. MDH is the perfect place to enjoy great food and drinks in a laid-back atmosphere.

Brews Brothers Taproom is a cozy bar located at 1105 Chestnut Street in Murphysboro, Illinois. With a wide selection of craft beers on tap and a laid-back atmosphere, it's the perfect spot to unwind and enjoy a drink with friends. The friendly staff and inviting decor make Brews Brothers Taproom a favorite among locals and visitors alike. Whether you're a beer enthusiast or just looking for a fun night out, this bar is sure to have something for everyone. So come on in, grab a pint, and relax at Brews Brothers Taproom.

Big Muddy Brewing is a popular food institution located in Murphysboro, Illinois. Situated at 1430 North 7th Street, this brewery offers a unique dining experience with a focus on delicious food and handcrafted beers. Whether you're looking for a casual meal or a place to unwind with friends, Big Muddy Brewing has something for everyone. Come and enjoy the cozy atmosphere, friendly service, and mouthwatering dishes at this must-visit spot in the heart of Murphysboro.

Hometown Pride Gifts & Sweets is a charming institution located at 1334 Walnut Street in Murphysboro, Illinois, United States. This unique establishment is a combination of a clothing store and a food store, offering a wide variety of locally-made gifts, apparel, and delicious sweets. Visitors can browse through a selection of stylish clothing items, accessories, and handcrafted gifts, while also treating themselves to a delectable assortment of sweets and treats. With a focus on showcasing the pride and creativity of the local community, Hometown Pride Gifts & Sweets is the perfect destination for those looking for a taste of small-town charm and hospitality.